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Public Health Well

FDA designates recall of several implanted cardiac pacemakers as class 1

The FDA has designated Medtronic’s product recall of implanted cardiac pacemakers as a class 1 recall, the most serious kind. The recall affects 13,440 devices manufactured and distributed between March 2, 2017, and Jan. 7, 2019. Possible circuit errors in ...

First-line enzalutamide, docetaxel combination improves disease control in advanced prostate cancer

SAN FRANCISCO — The addition of enzalutamide to docetaxel improved 6-month disease control and prolonged PFS as first-line therapy for men with metastatic castration-resistant prostate cancer, according to results from the CHEIRON study presented at Genito ...

CDC includes ‘homelessness’ as indication for hepatitis A vaccine

The CDC recently announced that all persons aged 1 year or older experiencing homelessness should be routinely immunized for hepatitis A, based on a review of recent data. “Among persons experiencing homelessness, effective implementation of alternative st ...

Hand-to-genital contact unlikely to cause HPV transmission

HPV transmission is unlikely to occur from hand-to-genital contact, and most infections are caused by genital-to-genital sexual transmission, according to a recent study published in The Lancet Infectious Diseases. “While hand-to-genital transmission has l ...

Age, radiographic OA seen as main drivers of appropriate use criteria for hip preservation surgery

Variables that contributed the most to the appropriateness classification system for hip preservation surgery published by the American Academy of Orthopaedic Surgeons included age and radiographic hip osteoarthritis evaluation, according to results. “Vari ...

Nivolumab plus ipilimumab shows activity in metastatic castration-resistant prostate cancer

SAN FRANCISCO — Nivolumab plus ipilimumab demonstrated activity in pretreated men with metastatic castration-resistant prostate cancer, according to initial findings from the phase 2 CheckMate 650 study presented at Genitourinary Cancers Symposium. In addi ...

Text message-based intervention shows promise for suicide prevention

Augmenting standard care with a text message-based intervention, known as Caring Contacts, did not decrease current suicidal ideation or suicide risk events at 12-month follow-up among active-duty military personnel in a randomized clinical trial. However, ...

FDA grants priority review to Keytruda as part of advanced kidney cancer regimen

The FDA granted priority review for a supplemental biologics license application seeking approval of pembrolizumab in combination with axitinib for first-line treatment of patients with advanced renal cell carcinoma, according to a press release from the m ...

Ascletis, 3-V Biosciences raise $18 million for phase 2 NASH therapy

3-V Biosciences has entered an exclusive license agreement with Ascletis Pharma for Ascletis to develop, manufacture and commercialize 3-V Biosciences’ nonalcoholic steatohepatitis therapy TVB-2640 in Greater China, according to a press release. 3-V Biosci ...

Small intestine bacterial overgrowth prevalence drastically higher in patients with IBD

There is a ninefold increase in the prevalence of small intestine bacterial overgrowth among patients with inflammatory bowel disease compared with other individuals, according to results of a meta-analysis. Gerald J. Holtmann, MD, PhD, MBA, of Princess Al ...

Higher push-up capacity decreases risk for CVD events

Patients with higher push-up capacity had a decreased risk for CVD events, according to a study published in JAMA Network Open. “Our findings provide evidence that push-up capacity could be an easy, no-cost method to help assess cardiovascular disease risk ...

Comparative study finds most effective bowel preps

A comparison study, published in the American Journal of Gastroenterology, found the most effective and best tolerated bowel preparations, which researchers hope will help provide some guidance on which one of the many commercially available options to use ...

Multiple CGM systems provide comparable performance, usability

Three continuous glucose monitoring systems were shown to provide similar accuracy in adults with type 1 diabetes compared with self-monitoring blood glucose, according to findings published in the Journal of Diabetes Science and Technology. “Since some CG ...

Do You Want to Be Pregnant? It’s Not Always a Yes-or-No Answer

New data on women’s uncertainty over motherhood may reshape how doctors and policymakers think about family planning. ...

HSE secures injunction over My Options website

The Health Service Executive has secured a temporary High Court injunction against a man who has allegedly set up a misleading website that is confusingly similar to the HSE's crisis pregnancy freephone service 'My Options'. ...

FDA approves interoperable insulin pump under new regulatory pathway

The FDA on Thursday approved marketing of the first insulin pump with interoperable technology for children and adults with diabetes, the first device to be classified under a new de novo premarket review pathway, the agency announced in a press release. ...

Moderate outcomes seen at 5-year follow-up after patellofemoral joint replacement

Results at 5-year follow-up showed the Femora Patella Vialli patellofemoral joint prosthesis yielded “moderate” outcomes, according to recently published results. Researchers identified 43 Femora Patella Vialli patellofemoral joint prostheses (Wright Medic ...

Serum catestatin may predict metabolic, CV risk in children, adolescents

Children and adolescents with obesity have lower levels of serum catestatin — an endogenous peptide found to be negatively associated with blood pressure level and insulin resistance — compared with children and adolescents with normal weight, according to ...

Common triggers for AF episodes modifiable

Common triggers for atrial fibrillation included caffeine, alcohol, lack of sleep and exercise, according to a study published in HeartRhythm. “Better understanding of individual-level triggers may help empower patients and represents a novel approach to i ...

Bivalirudin, heparin equally effective in elderly patients undergoing CTO PCI

Among elderly patients at high bleeding risk undergoing PCI for chronic total occlusion, bivalirudin was as safe and effective as unfractionated heparin, researchers reported. The researchers conducted a single-center randomized controlled trial of 123 pat ...