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Health Well

β-Cell Function Over Time in Adolescents With New Type 2 Diabetes and Obese Adolescents Without Diabetes

The progression of β-cell function in newly diagnosed adolescents with type 2 diabetes mellitus (T2DM) is not well documented. We hypothesized that at the time of diagnosis with T2DM, adolescents would have impaired β-cell function as demonstrated by the d ...

Diurnal Cortisol Interacts With Stressful Events to Prospectively Predict Depressive Symptoms in Adolescent Girls

The aim of present study was to test the diathesis-stress model of depression using baseline cortisol, prospective assessment of depression symptoms, and stressful life events. ...

Erratum to: Calcium vitamin D3 supplementation in clinical practice: side effect and satisfaction

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Cobalt nanoparticles induce lung injury, DNA damage and mutations in mice

We and other groups have demonstrated that exposure to cobalt nanoparticles (Nano-Co) caused oxidative stress and inflammation, which have been shown to be strongly associated with genotoxic and carcinogenic e... ...

Pathogens, Vol. 6, Pages 43: Emerging Roles of Heparanase in Viral Pathogenesis

Pathogens, Vol. 6, Pages 43: Emerging Roles of Heparanase in Viral Pathogenesis Pathogens doi: 10.3390/pathogens6030043 Authors: Neel Thakkar Tejabhiram Yadavalli Dinesh Jaishankar Deepak Shukla ...

Validation and Adaptation of the Danger Assessment-5 (DA-5): A Brief Intimate Partner Violence Risk Assessment

Absract Aims To assess the predictive validity of the DA-5 with the addition of a strangulation item in evaluating the risk of an intimate partner violence (IPV) victim being nearly killed by an intimate partner. ...

Systematic review and meta-analysis of non-pharmacological interventions to reduce the symptoms of mild to moderate anxiety in pregnant women

Abstract Aim To assess the effectiveness of non-pharmacological interventions for pregnant women with symptoms of mild to moderate anxiety. Background Many pregnant women experience mild to moderate symptoms of anxiety and could benefit from additional sup ...

The effect of infant feeding planning education on nutrition and breastfeeding knowledge, mother’s attitude, and husband’s support to expectant mother

Background: The issue of malnutrition that leads to food security is not just a technical issue, but also a matter of individual habit to meet nutrients needed, including nutrients for fetus. The Government agrees to address the issue of food security in ...

Treatment options and barriers to case management of neonatal pneumonia in India: a protocol for a scoping review

Introduction India contributes to the highest neonatal deaths globally. Case management is said to be the cornerstone of pneumonia control. Much of the published evidence focuses on children aged 1 to 59 months. This scoping review, thus, aims to identify ...

Burden of non-adherence to latent tuberculosis infection drug therapy and the potential cost-effectiveness of adherence interventions in Canada: a simulation study

Objective Pharmaceutical treatment of latent tuberculosis infection (LTBI) reduces the risk of progression to active tuberculosis (TB); however, poor adherence tempers the protective effect. We aimed to estimate the health burden of non-adherence, the maxi ...

Effectiveness, cost-utility and implementation of a decision aid for patients with localised prostate cancer and their partners: study protocol of a stepped-wedge cluster randomised controlled trial

Introduction Patient decision aids (PDAs) have been developed to help patients make an informed choice for a treatment option. Despite proven benefits, structural implementation falls short of expectations. The present study aims to assess the effectivenes ...

Qualitative interview study of parents perspectives, concerns and experiences of the management of lower respiratory tract infections in children in primary care

Objective To explore parents’ perspectives, concerns and experiences of the management of lower respiratory tract infections (LRTIs) in children in primary care. Design Qualitative semistructured interview study. Setting UK primary care. Participants 23 pa ...

'Just like a normal pain, what do people with diabetes mellitus experience when having a myocardial infarction: a qualitative study recruited from UK hospitals

Objective The objective of the study was to investigate the symptoms people with diabetes experience when having a myocardial infarction (MI), their illness narrative and how they present their symptoms to the health service. Setting Three London (UK) hosp ...

Combining CD4 recovery and CD4: CD8 ratio restoration as an indicator for evaluating the outcome of continued antiretroviral therapy: an observational cohort study

Objectives Immune recovery following highly active antiretroviral therapy (HAART) is commonly assessed by the degree of CD4 reconstitution alone. In this study, we aimed to assess immune recovery by incorporating both CD4 count and CD4:CD8 ratio. Design Ob ...

Prediction of early unplanned intensive care unit readmission in a UK tertiary care hospital: a cross-sectional machine learning approach

Objectives Unplanned readmissions to the intensive care unit (ICU) are highly undesirable, increasing variance in care, making resource planning difficult and potentially increasing length of stay and mortality in some settings. Identifying patients who ar ...

Post-traumatic growth and its relationship to quality of life up to 9 years after liver transplantation: a cross-sectional study in Spain

Objective Little is known concerning post-traumatic growth (PTG) after liver transplantation. Against this backdrop the current study analysed the relationship between PTG and time since transplantation on quality of life. Furthermore, it compared PTG betw ...

A protocol of a cross-sectional study evaluating an online tool for early career peer reviewers assessing reports of randomised controlled trials

Introduction Systematic reviews evaluating the impact of interventions to improve the quality of peer review for biomedical publications highlighted that interventions were limited and have little impact. This study aims to compare the accuracy of early ca ...

[Editorial] Life, death, and disability in 2016

In this week's issue of The Lancet, we publish the latest global, regional, and national estimates and analyses from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), covering the period 1990 to 2016. The GBD is a hercul ...

[Global Health Metrics] Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016

Globally, mortality rates have decreased across all age groups over the past five decades, with the largest improvements occurring among children younger than 5 years. However, at the national level, considerable heterogeneity remains in terms of both leve ...

[Global Health Metrics] Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

The past 37 years have featured declining rates of communicable, maternal, neonatal, and nutritional diseases across all quintiles of SDI, with faster than expected gains for many locations relative to their SDI. A global shift towards deaths at older ages ...

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