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Health Well

[World Report] 2017 Prince Mahidol Award winners announced

Public health prize recognises scientists who advanced the field of Haemophilus influenzae type b vaccination, and medicine award goes to the Human Genome Project. Andrew Green reports. ...

[Perspectives] Picturing health: Rohingya refugees in Bangladesh

Since August, 2017, when violence broke out in Myanmar's northern Rahkine State, it is estimated that more than 600 000 Rohingya people have fled to Bangladesh. To accommodate the steady flow of people, vegetation on steep hillsides and between swathe ...

[Correspondence] Charlottesville: blatant racism, not grievances, on display

We recently published a paper1 on structural racism in a Lancet Series on equity and equality in health in the USA. Structural racism refers to the many ways in which racial subjugation is embedded in US society—not just in one individual, or groups of ind ...

[Correspondence] Bisphosphonates in osteoporosis: NICE and easy?

The recent National Institute for Health and Care Excellence (NICE) updated multiple technology appraisal on bisphosphonate use in osteoporosis1 demonstrates how, for a common disorder, the strict application of cost-effectiveness thresholds for inexpensiv ...

[Correspondence] On evidence-based medicine

In their Review1 published in The Lancet (July 22, p 415), Benjamin Djulbegovic and Gordon H Guyatt provide a comprehensive overview of the challenges evidence-based medicine (EBM) will probably face in the next 25 years. Rightly, they conclude that it is ...

[Correspondence] On evidence-based medicine

In the Review1 of evidence-based medicine by Benjamin Djulbegovic and Gordon H Guyatt, different or conflicting interpretation of the literature was not mentioned. Although such data selection might not be deliberate, it can be problematic and could result ...

[Correspondence] On evidence-based medicine

In their Review,1 Benjamin Djulbegovic and Gordon H Guyatt do not adequately address the undue emphasis placed on randomisation in clinical research, which is arguably the main criticism of evidence-based medicine (EBM). ...

[Correspondence] On evidence-based medicine – Authors' reply

We thank Marjolein A van der Marck and colleagues, Feras Ali Mustafa, and Jan Matthys for their interest in our Review.1 We agree with van der Marck and colleagues that tackling multimorbidity is an enormous challenge for evidence-based practice that, so f ...

[Correspondence] Practical applications of evolutionary biology in public health

Jonathan Wells and colleagues,1 Grazyna Jasienska and colleagues,2 and Graham Rook and colleagues3 are to be congratulated on producing a fascinating and thought-provoking Series on how evolutionary biology could contribute to public health. The key insigh ...

AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70

Background/Aims: AQP2 expression is mainly controlled by vasopressin-dependent changes in protein abundance which is in turn regulated by AQP2 ubiquitylation and degradation, however the proteins involved in these processes are largely unknown. Here, we i ...

Diphthamide Biosynthesis 1 is a Novel Oncogene in Colorectal Cancer Cells and is Regulated by MiR-218-5p

Background/Aims: This study focused on the oncogenic role of Diphthamide biosynthesis 1 (DPH1) in colorectal cancer (CRC) cells. Methods: The expression of DPH1 was determined by quantitative RT-PCR analysis and western blotting in CRC tissues. The role o ...

MicroRNA Expression Profiling of Pancreatic Cancer Cell Line L3.6p1 Following B7-H4 Knockdown

Background/Aims: Co-stimulating molecule B7-H4 regulates T cell-mediated immune responses, participates in tumor immune escape, and promotes the proliferation and metastasis of pancreatic cancer cells. However, the specific mechanisms are unclear. MicroRN ...

Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice

Background/Aims: Retinitis pigmentosa (RP) is characterized by degeneration of photoreceptors, and there are currently no effective treatments for this disease. However, curcumin has shown neuroprotectant efficacy in a RP rat and swine model, and thus, ma ...

Huaier Extract Inhibits Breast Cancer Progression Through a LncRNA-H19/MiR-675-5p Pathway

Background/Aims: Increasing evidence indicates that Huaier extract has promising therapeutic effects against cancer. However, the mechanisms that underlie its anti-tumor effects remain unclear. In recent years, various studies have shown that long noncodi ...

LncRna CPS1-IT1 Suppresses Cell Proliferation, Invasion and Metastasis in Colorectal Cancer

Background/Aims: Increasing evidence demonstrates that long non-coding RNAs (lncRNAs) regulate diverse cellular processes and cancer progression. Whether lncRNAs play any functional role in colorectal carcinoma (CRC) remains largely unknown. The aim of th ...

Deficiency of Functional Iron-Sulfur Domains in ABCE1 Inhibits the Proliferation and Migration of Lung Adenocarcinomas By Regulating the Biogenesis of Beta-Actin In Vitro

Background/Aims: ATP-binding cassette transporter E1 (ABCE1), a unique ABC superfamily member that bears two Fe-S clusters, is essential for metastatic progression in lung cancer. Fe-S clusters within ABCE1 are crucial for ribosome dissociation and transl ...

Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species

Reactive oxygen species (ROS) are produced by living cells as normal cellular metabolic byproduct. Under excessive stress conditions, cells will produce numerous ROS, and the living organisms eventually evolve series of response mechanisms to adapt to the ...

Tackling the health burden of air pollution in South Asia

Air pollution exposure is the second most important risk factor for ill health in South Asia, contributing to between 13% and 21.7% of all deaths and approximately 58 million disability adjusted life... ...

Campaigners vow to fight on after report finds no link between hormone test and birth defects

Campaigners have called for a judicial review after a UK government report found that hormone based pregnancy tests (HPTs) given to women in the 1960s and 1970s did not cause birth defects.An expert... ...

Return to firm structure could help boost trainee morale, says Royal College of Surgeons

A training scheme that will create a modern firm structure could help to improve junior doctors’ morale, the Royal College of Surgeons has said.Earlier this month the college started recruiting to... ...

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