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Health Well

A pragmatic group sequential, placebo-controlled, randomised trial to determine the effectiveness of glyceryl trinitrate for retained placenta (GOT-IT): a study protocol

Introduction A retained placenta is diagnosed when the placenta is not delivered following delivery of the baby. It is a major cause of postpartum haemorrhage and treated by the operative procedure of manual removal of placenta (MROP). ...

The course and prognostic factors of cognitive status after central nervous system trauma: a systematic review protocol

Introduction Traumatic brain injury (TBI) is among the most disabling injuries, resulting in a range of cognitive impairments. Traumatic spinal cord injury (SCI) often occurs in conjunction with TBI; the two are best considered together in the context of t ...

Diagnostic validity of early-onset obsessive-compulsive disorder in the Danish Psychiatric Central Register: findings from a cohort sample

Objectives Employing national registers for research purposes depends on a high diagnostic validity. The aim of the present study was to examine the diagnostic validity of recorded diagnoses of early-onset obsessive-compulsive disorder (OCD) in the Danish ...

REACH: study protocol of a randomised trial of rehabilitation very early in congenital hemiplegia

Objectives Congenital hemiplegia is the most common form of cerebral palsy (CP). Children with unilateral CP show signs of upper limb asymmetry by 8 months corrected age (ca) but are frequently not referred to therapy until after 12 months ca. This study c ...

Protocol for a scoping review of skin self-care of people with spinal cord injury

Introduction In recent years, increasing methodological references have been used in scientific research; these are points of support in the search for evidence, formulation and elaboration of instruments, scales, guideline and protocols. However, signific ...

Impact of oral self-care on incident functional disability in elderly Japanese: the Ohsaki Cohort 2006 study

Objectives To assess whether oral self-care (tooth brushing, regular dental visits and use of dentures) affects incident functional disability in elderly individuals with tooth loss. Design A 5.7-year prospective cohort study. Setting Ohsaki City, Japan. P ...

Correction: Medication incidents in primary care medicine: a prospective study in the Swiss Sentinel Surveillance Network (Sentinella)

Gnädinger M, Conen D, Herzig L, et al. Medication incidents in primary care medicine: a prospective study in the Swiss Sentinel Surveillance Network (Sentinella). BMJ Open 2017; 7:e013658. doi: 10.1136/bmjopen-2016-013658 The main affiliation of author A ...

Correction: Consequences of maternal morbidity on health-related functioning: a systematic scoping review

Machiyama K, Hirose A, Cresswell JA, et al. Consequences of maternal morbidity on health-related functioning: a systematic scoping review. BMJ Open 2017; 7:e013903. doi: 10.1136/bmjopen-2016-013903 The Acknowledgements section for this paper should read: ...

Correction: Prevalence, clinical features and risk assessment of pre-diabetes in Spain: the prospective Mollerussa cohort study

Vilanova MB, Falguera M, Marsal JR, et al.  Prevalence, clinical features and risk assessment of pre-diabetes in Spain: the prospective Mollerussa cohort study.  BMJ Open 2017;7:e015158. doi: 10.1136/bmjopen-2016-015158 The name of the sixth author should ...

Correction: Interventions that improve maternity care for immigrant women in the UK: protocol for a narrative synthesis systematic review

Higginbottom GMA, Evans C, Morgan M, et al.  Interventions that improve maternity care for immigrant women in the UK: protocol for a narrative synthesis systematic review.  BMJ Open 2017;7:e016988. doi: 10.1136/bmjopen-2017-016988 The Corresponding author ...

Treatment options and barriers to case management of neonatal pneumonia in India: a protocol for a scoping review

Introduction India contributes to the highest neonatal deaths globally. Case management is said to be the cornerstone of pneumonia control. Much of the published evidence focuses on children aged 1 to 59 months. This scoping review, thus, aims to identify ...

Burden of non-adherence to latent tuberculosis infection drug therapy and the potential cost-effectiveness of adherence interventions in Canada: a simulation study

Objective Pharmaceutical treatment of latent tuberculosis infection (LTBI) reduces the risk of progression to active tuberculosis (TB); however, poor adherence tempers the protective effect. We aimed to estimate the health burden of non-adherence, the maxi ...

Effectiveness, cost-utility and implementation of a decision aid for patients with localised prostate cancer and their partners: study protocol of a stepped-wedge cluster randomised controlled trial

Introduction Patient decision aids (PDAs) have been developed to help patients make an informed choice for a treatment option. Despite proven benefits, structural implementation falls short of expectations. The present study aims to assess the effectivenes ...

Qualitative interview study of parents perspectives, concerns and experiences of the management of lower respiratory tract infections in children in primary care

Objective To explore parents’ perspectives, concerns and experiences of the management of lower respiratory tract infections (LRTIs) in children in primary care. Design Qualitative semistructured interview study. Setting UK primary care. Participants 23 pa ...

'Just like a normal pain, what do people with diabetes mellitus experience when having a myocardial infarction: a qualitative study recruited from UK hospitals

Objective The objective of the study was to investigate the symptoms people with diabetes experience when having a myocardial infarction (MI), their illness narrative and how they present their symptoms to the health service. Setting Three London (UK) hosp ...

Combining CD4 recovery and CD4: CD8 ratio restoration as an indicator for evaluating the outcome of continued antiretroviral therapy: an observational cohort study

Objectives Immune recovery following highly active antiretroviral therapy (HAART) is commonly assessed by the degree of CD4 reconstitution alone. In this study, we aimed to assess immune recovery by incorporating both CD4 count and CD4:CD8 ratio. Design Ob ...

Prediction of early unplanned intensive care unit readmission in a UK tertiary care hospital: a cross-sectional machine learning approach

Objectives Unplanned readmissions to the intensive care unit (ICU) are highly undesirable, increasing variance in care, making resource planning difficult and potentially increasing length of stay and mortality in some settings. Identifying patients who ar ...

Post-traumatic growth and its relationship to quality of life up to 9 years after liver transplantation: a cross-sectional study in Spain

Objective Little is known concerning post-traumatic growth (PTG) after liver transplantation. Against this backdrop the current study analysed the relationship between PTG and time since transplantation on quality of life. Furthermore, it compared PTG betw ...

A protocol of a cross-sectional study evaluating an online tool for early career peer reviewers assessing reports of randomised controlled trials

Introduction Systematic reviews evaluating the impact of interventions to improve the quality of peer review for biomedical publications highlighted that interventions were limited and have little impact. This study aims to compare the accuracy of early ca ...

[Editorial] Life, death, and disability in 2016

In this week's issue of The Lancet, we publish the latest global, regional, and national estimates and analyses from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), covering the period 1990 to 2016. The GBD is a hercul ...

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