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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Creator:

Willer, C. J. et al

Subject Keywords: Research article on weight regulation and genes associated with body mass index
Topic: Cardiovascular Health (Draft)
Obesity
Obesity
Type: Website
Region: International (other)
Description:

Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 times 10-8): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.

Date:

01/01/2009

Rights: © Willer, C. J. et al
Suggested citation:

Willer, C. J. et al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation [Online]. Available from: http://publichealthwell.ie/node/3953 [Accessed: 22nd August 2019].

  

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