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Pregabalin monotherapy for epilepsy

Creator:

Zhou, Q., Zheng, J., Yu, L. and Jia, X.

Subject Keywords: To determine the efficacy and tolerability of pregabalin in people with epilepsy
Type: Article
Region: International (other)
Description:

A number of people continue to have seizures and many experience adverse effects, despite current antiepileptic treatments. As a result, there is increasing interest in new pharmacological treatment options such as pregabalin. This systematic review evaluated the efficacy and tolerability of pregabalin in people with epilepsy. The review authors only included two, short-term randomised controlled trials involving 753 participants treated with pregabalin monotherapy for epilepsy. Studies included in this review suggested that pregabalin was inferior to lamotrigine but was better than gabapentin, but we found some limitations in the study design which may have had a great influence on the results. There is no strong evidence to support its monotherapy as a treatment for epilepsy. Long-term trials and high quality randomised clinical trials are needed to evaluate the efficacy and safety of pregabalin monotherapy for treating epilepsy.

Date:

17/10/2012

Rights: © The Cochrane Collaboration
Suggested citation:

Zhou, Q., Zheng, J., Yu, L. and Jia, X.. (2012) Pregabalin monotherapy for epilepsy [Online]. Available from: http://publichealthwell.ie/node/301890 [Accessed: 22nd August 2019].

  

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