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Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery


Sanders, R.D., et al

Subject Keywords: The authors examined whether short-term statin therapy, commenced before or on the day of noncardiac vascular surgery and continuing for at least 48 hours afterwards, improves patient outcomes including the risk of complications, pain, quality of life and length of hospital stay
Type: Article
Region: International (other)

Patients undergoing vascular surgery often have widespread atherosclerosis and are at high risk of complications during and after the operation. (Atherosclerosis is a condition in which an artery wall thickens as the result of an accumulation of fatty deposits such as cholesterol.) Statins are widely used to treat raised cholesterol levels but also confer beneficial effects on the inflammatory and circulatory systems. Their long-term use in patients with vascular disease is well established. Accumulating evidence suggests that short-term treatment with statins may reduce complications after cardiac surgery, but it is not yet clear whether there are any benefits for vascular surgery patients.   

In July 2012 the authors searched medical databases for controlled trials of participants who had undergone aortic or arterial surgery and were randomly assigned to either statins or placebo (or standard care). Many vascular surgery patients are already taking statins; therefore we also included trials that randomly assigned participants to different doses of statin. Statin treatment should have been started any time between the decision to operate and performance of the operation and continued for at least 48 hours after the operation. They wanted to investigate the effect of this short-term statin therapy on the risk of death and cardiovascular events such as heart attack and stroke within 30 days of surgery. They also considered adverse effects of statins such as muscle pain.



Rights: © The Cochrane Collaboration
Suggested citation:

Sanders, R.D., et al. (2013) Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery [Online]. Available from: [Accessed: 24th August 2019].


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