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Obesity-Blocking Neurons in Drosophila


Al-Anzi, B. et al

Subject Keywords: Study on Obesity-Blocking Neurons in Fruit Flies
Topic: Obesity
Type: Website
Region: International (other)

In mammals, fat store levels are communicated by leptin and insulin signaling to brain centers that regulate food intake and metabolism. By using transgenic manipulation of neural activity, the authors report the isolation of two distinct neuronal populations in flies that perform a similar function, the c673a-Gal4 and fruitless-Gal4 neurons. When either of these neuronal groups is silenced, fat store levels increase. This change is mediated through an increase in food intake and altered metabolism in c673a-Gal4-silenced flies, while silencing fruitless-Gal4 neurons alters only metabolism. Hyperactivation of either neuronal group causes depletion of fat stores by increasing metabolic rate and decreasing fatty acid synthesis. Altering the activities of these neurons causes changes in expression of genes known to regulate fat utilization. The results show that the fly brain measures fat store levels and can induce changes in food intake and metabolism to maintain them within normal limits.



Rights: © Al-Anzi, B. et al
Suggested citation:

Al-Anzi, B. et al. (2009) Obesity-Blocking Neurons in Drosophila [Online]. Available from: [Accessed: 24th August 2019].


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