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Methodology in conducting a systematic review of systematic reviews of healthcare interventions.



Subject Keywords: Healthcare; Maternity care interventions;
Catalogue: Research and Evaluation
Type: Article
Region: Republic of Ireland

Background: Hundreds of studies of maternity care interventions have been published, too many for most people
involved in providing maternity care to identify and consider when making decisions. It became apparent that
systematic reviews of individual studies were required to appraise, summarise and bring together existing studies
in a single place. However, decision makers are increasingly faced by a plethora of such reviews and these are
likely to be of variable quality and scope, with more than one review of important topics. Systematic reviews (or
overviews) of reviews are a logical and appropriate next step, allowing the findings of separate reviews to be
compared and contrasted, providing clinical decision makers with the evidence they need.
Methods: The methods used to identify and appraise published and unpublished reviews systematically, drawing
on our experiences and good practice in the conduct and reporting of systematic reviews are described. The
process of identifying and appraising all published reviews allows researchers to describe the quality of this
evidence base, summarise and compare the review’s conclusions and discuss the strength of these conclusions.
Results: Methodological challenges and possible solutions are described within the context of (i) sources, (ii) study
selection, (iii) quality assessment (i.e. the extent of searching undertaken for the reviews, description of study
selection and inclusion criteria, comparability of included studies, assessment of publication bias and assessment of
heterogeneity), (iv) presentation of results, and (v) implications for practice and research.
Conclusion: Conducting a systematic review of reviews highlights the usefulness of bringing together a summary
of reviews in one place, where there is more than one review on an important topic. The methods described here
should help clinicians to review and appraise published reviews systematically, and aid evidence-based clinical

Rights: © Public
Suggested citation:

SMITH, VALERIE; BEGLEY, CECILY MARION; . () Methodology in conducting a systematic review of systematic reviews of healthcare interventions. [Online]. Available from: [Accessed: 21st May 2019].


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