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Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently 'safe' levels of alcohol during pregnancy? A systematic review and meta-analyses.

Creator:

Loubaba Mamluk, Hannah B Edwards, Jelena SavoviÄ?, Verity Leach, Timothy Jones, Theresa H M Moore, Sharea Ijaz, Sarah J Lewis, Jenny L Donovan, Debbie Lawlor, George Davey Smith, Abigail Fraser, Luisa Zuccolo

Type: Article
Region: Republic of Ireland
Northern Ireland
Description:

OBJECTIVES: To determine the effects of low-to-moderate levels of maternal alcohol consumption in pregnancy on pregnancy and longer-term offspring outcomes. SEARCH STRATEGY: Medline, Embase, Web of Science and Psychinfo from inception to 11 July 2016. SELECTION CRITERIA: Prospective observational studies, negative control and quasiexperimental studies of pregnant women estimating effects of light drinking in pregnancy (â?¤32â??g/week) versus abstaining. Pregnancy outcomes such as birth weight and features of fetal alcohol syndrome were examined. DATA COLLECTION AND ANALYSIS: One reviewer extracted data and another checked extracted data. Random effects meta-analyses were performed where applicable, and a narrative summary of findings was carried out otherwise. MAIN RESULTS: 24 cohort and two quasiexperimental studies were included. With the exception of birth size and gestational age, there was insufficient data to meta-analyse or make robust conclusions. Odds of small for gestational age (SGA) and preterm birth were higher for babies whose mothers consumed up to 32â??g/week versus none, but estimates for preterm birth were also compatible with no association: summary OR 1.08, 95% CI (1.02 to 1.14), I(2) 0%, (seven studies, all estimates were adjusted) OR 1.10, 95%â??CI (0.95 to 1.28), I(2) 60%, (nine studies, includes one unadjusted estimates), respectively. The earliest time points of exposure were used in the analysis. CONCLUSION: Evidence of the effects of drinking â?¤32â??g/week in pregnancy is sparse. As there was some evidence that even light prenatal alcohol consumption is associated with being SGA and preterm delivery, guidance could advise abstention as a precautionary principle but should explain the paucity of evidence.

Date:

01/08/2017

Rights: Public
Suggested citation:

Loubaba Mamluk, Hannah B Edwards, Jelena SavoviÄ?, Verity Leach, Timothy Jones, Theresa H M Moore, Sharea Ijaz, Sarah J Lewis, Jenny L Donovan, Debbie Lawlor, George Davey Smith, Abigail Fraser, Luisa Zuccolo. (2017) Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently 'safe' levels of alcohol during pregnancy? A systematic review and meta-analyses. [Online]. Available from: http://publichealthwell.ie/node/1116698 [Accessed: 17th July 2019].

  

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National Drugs Library
 
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