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ECM-based materials in cardiovascular applications: inherent healing potential and augmentation of native regenerative processes

Creator:

Piterina, Anna Valentinova; Cloonan, Aidan J.; Meaney, Claire L.; Davis, Laura M.; Callanan, Anthony; Walsh, Michael T.; McGloughlin, Timothy M.;

Institution: MDPIAG
Subject Keywords: vascular grafts; ECM; healing process;
Topic: Cardiovascular Health (Draft)
Chronic Conditions
Conditions
Coronary Heart Disease (CHD)
Catalogue: Research and Evaluation
Report
Type: Report
Region: Republic of Ireland
Description:

The in vivo healing process of vascular grafts involves the interaction of many
contributing factors. The ability of vascular grafts to provide an environment which allows
successful accomplishment of this process is extremely difficult. Poor endothelisation,
inflammation, infection, occlusion, thrombosis, hyperplasia and pseudoaneurysms are
common issues with synthetic grafts in vivo. Advanced materials composed of
decellularised extracellular matrices (ECM) have been shown to promote the healing
process via modulation of the host immune response, resistance to bacterial infections,
allowing re-innervation and reestablishing homeostasis in the healing region. The
physiological balance within the newly developed vascular tissue is maintained via the
recreation of correct biorheology and mechanotransduction factors including host immune
response, infection control, homing and the attraction of progenitor cells and infiltration by
host tissue. Here, we review the progress in this tissue engineering approach, the
enhancement potential of ECM materials and future prospects to reach the
clinical environment.

Suggested citation:

Piterina, Anna Valentinova; Cloonan, Aidan J.; Meaney, Claire L.; Davis, Laura M.; Callanan, Anthony; Walsh, Michael T.; McGloughlin, Timothy M.; . () ECM-based materials in cardiovascular applications: inherent healing potential and augmentation of native regenerative processes [Online]. Available from: http://publichealthwell.ie/node/663448 [Accessed: 13th November 2019].

  

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RIAN
 
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