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Curcumin for maintenance of remission in ulcerative colitis


Kumar, S., et al

Subject Keywords: Ulcerative colitis (UC), Chronic inflammatory condition
Type: Article
Region: International (other)

Curcumin is a natural anti-inflammatory agent that is often used in many chronic inflammatory conditions including rheumatoid arthritis, esophagitis and post-surgical inflammation. The purpose of this systematic review was to examine the effectiveness and safety of curcumin therapy for the maintenance of remission in patients with ulcerative colitis (UC), a chronic inflammatory condition of the colon. Currently available agents for the management of this condition have been reported to result side effects, particularly when used for prolonged periods.

This review includes one randomized trial with a total of 89 participants. All patients received treatment with sulfasalazine or mesalamine (drugs containing 5-aminosalicylic acid). Fewer patients in the curcumin group relapsed at six months compared to patients who received placebo (e.g. fake drug). However, this result was not statistically significant. Patients in the curcumin group had significantly lower disease activity index and endoscopic index scores at six months than patients in the placebo group. No serious side effects were reported. A total of nine mild side effects were reported in seven patients. These side effects included a sensation of abdominal bulging, nausea, a brief increase in blood pressure, and a brief increase in the number of stools.

The results of this systematic review suggest that curcumin may be a safe and effective therapy for maintenance of remission in ulcerative colitis when given as additional therapy with mesalamine or sulfasalazine. Further research is needed to confirm any possible benefit of curcumin for maintenance therapy in ulcerative colitis.



Rights: © The Cochrane Collaboration
Suggested citation:

Kumar, S., et al. (2012) Curcumin for maintenance of remission in ulcerative colitis [Online]. Available from: [Accessed: 24th August 2019].


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