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Clinical risk factors for osteoporosis in Ireland and the UK: a comparison of FRAX and QFracturescores

Creator:

Cummins, Niamh M; Poku, E.K.; Towler, M.R; O'Driscoll, O.M.; Ralston, S.R.;

Institution: Springer-Verlag
Subject Keywords: clinical risk factors; osteoporosis; fracture; FRAXX;
Region:
Description:

Introduction: Recently two algorithms have become available to estimate the 10-year
probability of fracture in patients suspected to have osteoporosis on the basis of
clinical risk factors (CRF); the FRAX algorithm and QFractureScores algorithm
(QFracture). The aim of this study was to compare the performance of these
algorithms in a study of fracture patients and controls recruited from six centres in the
UK and Ireland.
Methods: A total of 246 postmenopausal women aged 50-85 years who had recently
suffered a low trauma fracture were enrolled and their characteristics were compared
with 338 female controls who had never suffered a fracture. Measurements of femoral
bone mineral density (BMD) were performed by dual energy X-ray absorptiometry
(DXA) and fracture risk was calculated using the FRAX and QFracture algorithms.
Results: The FRAX algorithm yielded higher calculated scores for fracture risk than
the QFracture algorithm. Accordingly, the risk of major fracture in the overall study
group was 9.5% for QFracture compared with 15.2% for FRAX. For hip fracture risk
the values were 2.9% and 4.7% respectively. The correlation between FRAX and
QFracture was R=0.803 for major fracture and R=0.857 for hip fracture (p≤0.0001).
Both algorithms yielded high specificity but poor sensitivity for prediction of
osteoporosis.
Conclusions: We conclude that the FRAX and QFracture algorithms yield similar
results in the estimation of fracture risk. Both of these tools could be of value in
primary care to identify patients in the community at risk of osteoporosis and fragility
fractures for further investigation and therapeutic intervention.

Suggested citation:

Cummins, Niamh M; Poku, E.K.; Towler, M.R; O'Driscoll, O.M.; Ralston, S.R.; . () Clinical risk factors for osteoporosis in Ireland and the UK: a comparison of FRAX and QFracturescores [Online]. Available from: http://publichealthwell.ie/node/666264 [Accessed: 22nd October 2019].

  

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