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Chronic Obstructive Pulmonary Disease: evidence for and autoimmune component.

Institution: Chinese Society of Immunology
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Chronic obstructive pulmonary disease (COPD) is characterized by an irreversible limitation on pulmonary
airflow associated with chronic inflammation and mucous hypersecretion (chronic bronchitis) and/or the
pathological destruction of alveolar airspaces leading to emphysema. COPD, predominantly as a result of tobacco
smoke exposure, represents the fourth leading cause of mortality worldwide and its prevalence is increasing.
Despite this, much of the basic mechanisms which contribute to disease progression remain to be elucidated and
current therapeutic approaches are, for the most part, based upon alleviating patient symptoms (bronchodilators)
as opposed to treating the underlying pathological mechanisms triggered in response to cigarette smoke exposure.
The classic disease paradigm suggests that an imbalance of pulmonary matrix proteases versus anti-proteases
underlies the tissue destruction and inflammation associated with COPD. However, there is a growing appreciation
of the complex and multifaceted nature of the pathological mechanisms associated with disease progression.
Recently, there has been mounting evidence indicating that COPD patients exhibit many of the characteristics of a
classical autoimmune response. We will discuss current evidence in support of this paradigm and outline how
future therapeutic approaches may be tailored to address this. Cellular & Molecular Immunology. 2009;6(2):81-86

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Related: http://www.cmi.ustc.edu.cn/6/2/81.pdf
Suggested citation:

. () Chronic Obstructive Pulmonary Disease: evidence for and autoimmune component. [Online]. Available from: http://www.thehealthwell.info/node/624243 [Accessed: 15th December 2017].

  

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