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CCBYNC Open access Research Psychological distress in relation to site specific cancer mortality: pooling of unpublished data from 16 prospective cohort studies

Creator:

The British Medical Journal

Type: Article
Region: Republic of Ireland
Northern Ireland
Description:

Objective To examine the role of psychological distress (anxiety and depression) as a potential predictor of site specific cancer mortality.

Design Pooling of individual participant data from 16 prospective cohort studies initiated 1994-2008.

Setting Nationally representative samples drawn from the health survey for England (13 studies) and the Scottish health survey (three studies).

Participants 163â??363 men and women aged 16 or older at study induction, who were initially free of a cancer diagnosis, provided self reported psychological distress scores (based on the general health questionnaire, GHQ-12) and consented to health record linkage.

Main outcome measure Vital status records used to ascertain death from 16 site specific malignancies; the three Scottish studies also had information on cancer registration (incidence).

Results The studies collectively contributed an average of 9.5 years of mortality surveillance during which there were 16â??267 deaths (4353 from cancer). After adjustment for age, sex, education, socioeconomic status, body mass index (BMI), and smoking and alcohol intake, and with reverse causality (by left censoring) and missing data (by imputation) taken into account, relative to people in the least distressed group (GHQ-12 score 0-6), death rates in the most distressed group (score 7-12) were consistently raised for cancer of all sites combined (multivariable adjusted hazard ratio 1.32, 95% confidence interval 1.18 to 1.48) and cancers not related to smoking (1.45, 1.23 to 1.71), as well as carcinoma of the colorectum (1.84, 1.21 to 2.78), prostate (2.42, 1.29 to 4.54), pancreas (2.76, 1.47 to 5.19), oesophagus (2.59, 1.34 to 5.00), and for leukaemia (3.86, 1.42 to 10.5). Stepwise associations across the full range of distress scores were observed for colorectal and prostate cancer.

Date:

01/02/2017

Rights: Public
Suggested citation:

The British Medical Journal. (2017) CCBYNC Open access Research Psychological distress in relation to site specific cancer mortality: pooling of unpublished data from 16 prospective cohort studies [Online]. Available from: http://www.thehealthwell.info/node/1070677 [Accessed: 24th September 2017].

  

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Contributor:

Northern Ireland Cancer Network (NICaN)
 
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