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The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation

Creator:

Science Translational Medicine

Subject Keywords: Breast Cancer
Set: Chronic Conditions
Conditions
Cancer
Catalogue: Research and Evaluation
Other Outputs
Type: Article
Region: Republic of Ireland
Northern Ireland
Description:

Although targeted therapies are often effective systemically, they fail to adequately control brain metastases. In preclinical models of breast cancer that faithfully recapitulate the disparate clinical responses in these microenvironments, we observed that brain metastases evade phosphatidylinositide 3-kinase (PI3K) inhibition despite drug accumulation in the brain lesions. In comparison to extracranial disease, we observed increased HER3 expression and phosphorylation in brain lesions.

Date:

30/05/2017

Rights: © Public
Suggested citation:

Science Translational Medicine. (2017) The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation [Online]. Available from: http://www.thehealthwell.info/node/1097444 [Accessed: 19th October 2017].

  

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Contributor:

Northern Ireland Cancer Network (NICaN)
 
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