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Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation

Creator:

Horsley, A. and Jones, A.M.

Subject Keywords: Antibiotic regimen, Cystic fibrosis, Exacerbation, Chronical infection, Burkholderia cepacia complex
Topic: Chronic Conditions
Conditions
Chronic Conditions
Type: Article
Region: International (other)
Description:

Cystic fibrosis is a common inherited condition where the lungs often become blocked with mucus. This harms the lungs' defences and often results in chronic, persistent infections that cannot be cleared by antibiotics. People with cystic fibrosis often need courses of antibiotics to reduce their symptoms (for instance cough, excess mucus and breathlessness) when these worsen. Such episodes are called exacerbations, and are usually treated with intravenous antibiotics (given through a drip into a vein). One group of bacteria that can infect the lungs of people with cystic fibrosis is called the Burkholderia cepacia complex. These closely-related bacteria are found widely in the environment and do not cause infections in healthy people who do not have cystic fibrosis. They are particularly hard to treat as they are resistant to many commonly-used antibiotics. Currently doctors do not know which antibiotics are best at treating these infections; which combinations of antibiotics should be used; how long the antibiotics should be used for; or whether there are additional treatments that might also help. This review aimed to address these questions, but we did not find any randomised controlled trials that compared treatments for exacerbations in cystic fibrosis patients who were infected with Burkholderia cepacia complex bacteria. More research is needed to find out which treatments are best for improving lung function and survival and for reducing side effects and length of time spent in hospital for these patients.

Date:

17/10/2012

Rights: © The Cochrane Collaboration
Suggested citation:

Horsley, A. and Jones, A.M.. (2012) Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation [Online]. Available from: http://publichealthwell.ie/node/301629 [Accessed: 20th November 2019].

  

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