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Tracking the Evolution of Non-Small-Cell Lung Cancer

Among patients with nonâ?"small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity in relation to cl ...

A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability

Mutations truncating a single copy of the tumor suppressor, BRCA2, cause cancer susceptibility. In cells bearing such heterozygous mutations, we find that a cellular metabolite and ubiquitous environmental toxin, formaldehyde, stalls and destabilizes DNA ...

Dietary sugar intake increases liver tumor incidence in female mice

Overnutrition can promote liver cancer in mice and humans that have liver damage caused by alcohol, viruses, or carcinogens. However, the mechanism linking diet to increased liver tumorigenesis remains unclear in the context of whether tumorigenesis is se ...

Cumulative risk of breast cancer screening outcomes according to the presence of previous benign breast disease and family history of breast cancer: supporting personalised screening

Background: Our aim was to assess the cumulative risk of false-positive screening results, screen-detected cancer, and interval breast cancer in mammography screening among women with and without a previous benign breast disease and a family history of br ...

Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe

We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), wh ...

The Effect of Multiple Chronic Conditions on Self-Rated Health, Disability and Quality of Life Among the Older Populations of Northern Ireland and the Republic of Ireland

10.14655/11971-1058471 Mark Hanly, Olga McDaid, Kathryn Richardson, George Savva Self-rated health, Disability, Disabled People, Quality of Life Article   in   Irish Journal of Medical Science 181:S273-S273  · September 2012 Chronic Conditions Conditions ...

The effect of multiple chronic conditions on self-rated health, disability and quality of life among the older populations of Northern Ireland and the Republic of Ireland: A comparison of two nationally representative cross-sectional surveys

10.14655/11971-1058466 Olga McDaid, Mark J Hanly, Kathryn Richardson, George M Savva Multimorbidity, Older People, Disability, Quality of Life Multimorbidity is common in the older population, but the impact of combinations of chronic conditions on disabi ...

Age does not hamper the response to pulmonary rehabilitation of COPD patients

Background: pulmonary rehabilitation (PR) improves health status and exercise tolerance, but not respiratory function in patients with chronic obstructive pulmonary disease (COPD). Our objective was to identify predictors of improvement in the 6-min walke ...