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Systematic reviews

Pegylated liposomal doxorubicin for relapsed epithelial ovarian cancer

Lawrie, T.A., et al To assess the efficacy and safety of PLD in women with relapsed epithelial ovarian cancer (EOC) The choice of chemotherapy in women with relapsed epithelial ovarian cancer (EOC) is influenced by the duration of the platinum-free interv ...

Low molecular weight heparin for prevention of microvascular occlusion in digital replantation

Chen, Y., et al Subcutaneous LMWH treatment, Digits, Patients, Digital replantation, Traumatic amputation Microvascular surgery refers to any surgery involving small sized blood vessels that is performed under the operating microscope, allowing the repair ...

Interventions to promote informed consent for patients undergoing surgical and other invasive healthcare procedures

Kinnersley, P., et al Patients, Clinicians, Healthcare system, Surgical procedures, Invasive healthcare treatments Before patients have an operation or other invasive procedure (e.g. endoscopy) it is crucial for the healthcare professional to explain what ...

CHIVA method for the treatment of chronic venous insufficiency

Bellmunt-Montoya, S., et al CHIVA method, Alternative therapeutic technique, Varicose veins Chronic venous insufficiency (CVI) is a disorder in which veins fail to pump blood back to the heart adequately. It can cause varicose veins, skin ulcers, and supe ...

Anthracycline-containing regimens for treatment of follicular lymphoma in adults

Itchaki, G., et al ACRs, Chemotherapy regimens, Treatment FL is the most common indolent non-Hodgkin's lymphoma (NHL). It is a slowly progressive disease, with a risk of transformation to a more aggressive lymphoma. Advanced disease (stage III and IV ...

Acupuncture for stress urinary incontinence in adults

Wang, Y., et al Acupuncture, Stress urinary incontinence, Adults Stress urinary incontinence is a common disease among older people, especially women. The symptoms are leakage of urine when the person coughs, laughs or exercises. It affects social, psycho ...

Acetaminophen (paracetamol) for the common cold in adults

Li, S., et al Safety, Aetaminophen, Treatment, Common cold, Adult The common cold is the most frequent viral infection of the upper respiratory tract. Adults in the US experience two to four colds per year. The symptoms of the common cold usually include ...

Efficacy of motivational interviewing for smoking cessation: A systematic review and meta-analysis

Heckman, C.J. and Egleston, B.. Smoking cessation A systematic review and meta-analysis to investigate the efficacy of interventions incorporating motivational interviewing for smoking cessation and identify correlates of treatment effects. Systematic Rev ...

Interventions for Promoting Reintegration and Reducing Harmful Behaviour and Lifestyles in Street-connected Children and Young People: A Systematic Review

Coren, E., et al Interventions, Street-connected children Numbers of street-connected children and young people run into many millions worldwide and include children and young people who live or work in street environments. Whether or not they remain conn ...

Deep Impact: Unintended consequences of journal rank

Brembs, B. and Munafo, < Open Access publishing Most researchers acknowledge an intrinsic hierarchy in the scholarly journals (‘journal rank’) that they submit their work to, and adjust not only their submission but also their reading strategies accord ...

Exploring the Effects of a Transition to Open Access: Insights from a Simulation Study

Bernius, S., et al Open Access publishing The Open Access (OA) movement, which postulates gratis and unrestricted online access to publicly funded research findings, has significantly gained momentum in recent years. The two ways of achieving OA are self- ...

Wound drainage after plastic and reconstructive surgery of the breast

Stojkovic, C.A., et al To compare the safety and efficacy of the use of wound drains following elective plastic and reconstructive surgery procedures of the breast Plastic and reconstructive surgery of the breast can include breast enlargement, breast red ...

Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia

Declercq, T., et al To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia in community or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older people with deme ...

Vasopressin and its analogues for the treatment of refractory hypotension in neonates

shivanna, B., et al The rimary objective was to evaluate the efficacy and safety of vasopressin and its synthetic analogues (e.g. terlipressin) in decreasing mortality and adverse neurodevelopmental outcomes, and improving survival in neonates with refrac ...

Thromboprophylaxis for trauma patients

Barrera, L.M., et al To assess the effects of thromboprophylaxis in trauma patients on mortality and incidence of deep vein thrombosis and pulmonary embolism. To compare the effects of different thromboprophylaxis interventions and their effects according ...

The role of maintenance therapy in acute promyelocytic leukemia in the first complete remission

Muchtar, E., et al To examine the efficacy and safety of maintenance therapy in APL patients and to establish the optimal regimen for maintenance Acute promyelocytic leukemia (APL) is a subtype of acute myelogenous leukemia (AML), comprising about 10% of ...

Sulthiame add-on therapy for epilepsy

Milburn-McNulty, P., et al To compare the efficacy and side-effect profile of sulthiame as add-on therapy compared with placebo or another antiepileptic drug Epilepsy is a common neurological condition which is characterised by recurrent seizures. The maj ...

Subintimal angioplasty for chronic lower limb arterial occlusion

Zhi Hui Chang and Zhao Yu Liu To assess the effectiveness of SIA versus any other treatment for patients with chronic lower limb artery occlusion. This will be determined by the effects on clinical improvement, technical success rate, patency rate, limb s ...

Stent graft types for endovascular repair of thoracic aortic aneurysms

Rolph, R., et al This review aimed to assess the different stent graft types for endovascular repair of thoracic aortic aneurysms An aneurysm is a localised widening of an artery. The thoracic aorta is the largest artery in the body, delivering blood from ...

Stent graft types for endovascular repair of abdominal aortic aneurysms

Duffy, J.M.N., et al This review aimed to assess the different stent graft types for endovascular repair of AAA An aneurysm is a localised widening of an artery. The abdominal aorta is the largest artery in the body, delivering blood from the heart to the ...