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DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition

Dietary restriction extends lifespan in diverse organisms, but the gene regulatory mechanisms and tissues mediating the increased survival are still unclear. Studies in worms and flies have revealed a number of candidate mechanisms, including the target o ...

Visual Impairment in Alzheimer's Disease: A Critical Review

Visual impairment is a common symptom of Alzheimer’s disease (AD). Recent studies have demonstrated the potential of visual interventions to improve the functioning of AD patients. Therefore, clarification of the profile of visual deficits in AD and possi ...

Could martial arts fall training be safe for persons with osteoporosis?: a feasibility study

BackgroundOsteoporosis is a well-established risk factor for fall-related hip fractures. Training fall arrest strategies, such as martial arts (MA) fall techniques, might be useful to prevent hip fractures in persons with osteoporosis, provided that the t ...

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

Genetic overexpression of protein deacetylase Sir2 increases longevity in a variety of lower organisms, and this has prompted interest in the effects of its closest mammalian homologue, Sirt1, on ageing and cancer. We have generated transgenic mice modera ...

Intergenerational Solidarity: the Way forward- Age Platform (EU)

A group of European NGO's have come together to call for 2012 to become the European Year of Active Ageing and Intergenerational Solidarity. They will launch their proposal on Thursday 29th April, which is the second European Day on Solidarity betwee ...

Rosuvastatin for Primary Prevention in Older Persons With Elevated C-Reactive Protein...

Background: Randomized data on statins for primary prevention in older persons are limited, and the relative hazard of cardiovascular disease associated with an elevated cholesterol level weakens with advancing age. Objective: To assess the efficacy and s ...

Statins for Primary Prevention in Older Adults: Who Is High Risk, Who Is Old, and What Denotes Primary Prevention?

Whether to treat older adults with statin medications for primary prevention of cardiovascular events remains a clinical conundrum. This editorial discusses the exploratory analysis of patients 70 years or older in a trial that compared 20 mg/d of rosuvas ...

Rosuvastatin to Prevent Heart Problems and Stroke in Persons 70 Years or Older

What is the problem and what is known about it so far? Low-density lipoprotein (LDL) cholesterol is the “bad” cholesterol that increases a person's risk for cardiovascular disease (heart problems or stroke). C-reactive protein is another substance in ...

Alzheimer's Disease and Cognitive Decline

Objectives: To assess whether previous research on purported risk or protective factors for Alzheimer's disease (AD) and cognitive decline is of sufficient strength to warrant specific recommendations for behavioral, lifestyle, or pharmaceutical inte ...

"A new era for longitudinal studies": Longitudinal and Life Course Studies Journal Vol 2

Governments worldwide are recognising the importance of long term evidence in policy making and are making significant investments in longitudinal research resources. The UK, France, Ireland, Germany and Australia have all established new longitudinal stu ...

New Study Characterises Cognitive And Anatomic Differences In Alzheimer's Disease Gene Carriers

In the most comprehensive study to date, neurologists have clearly identified significant differences in the ways that Alzheimer's disease (AD) affects patients with and without the apolipoprotein E ε4 gene (APOE ε4), a known genetic risk factor for ...

Priorities for Action 2010/11: Northern Ireland Department of Health, Social Services and Public Safety

Northern Ireland Health Minister, Michael McGimpsey recently announced the publication of Priorities for Action 2010/11 for the Department of Health, Social Services and Public Safety.The Priorities for Action 2010-11 identifies seven key areas:· Improvin ...

Vitamin D and the prevention of falls: has the time come?

This article on Vitamin D and health and disease by John Robbins was recently published in Future Medicine. The full article is available below:Vitamin D and the prevention of falls: has the time come?SummaryVitamin D appears to be taking the place of vit ...

Treating the Aged in Rural Communities: The Application of Cognitive-Behavioral Therapy for Depression

Many rural communities are experiencing an increase in their older adult population. Older adults who live in rural areas typically have fewer resources and poorer mental and physical health status than do their urban counterparts.Depression is the most p ...

Use of Statin Therapy to Reduce Cardiovascular Risk in Older Patients: Review

Cardiovascular disease is the principal cause of mortality in older individuals, and more than 80% of deaths due to coronary heart disease or stroke occur in patients over 65 years of age. Hyperlipidemia is one of the main modifiable risk factors for card ...

Function-Focused Care for LTC Residents with Moderate-to-Severe Dementia: A Social Ecological Approach

Over one-third of long-term care (LTC) residents exhibit moderate-to-severe cognitive impairment. These residents are more likely to be inactive, require assistance with activities of daily living, have medical comorbidities, and be exposed to fewer oppor ...

Prevention of Overuse of Wheelchairs in Nursing Homes: US study

The number of nursing home residents in the United States is projected to reach three million by the year 2030. Currently, over 80% of residents spend time sitting in a wheelchair every day. Many of these residents are overlooked for therapeutic treatment ...

Diabetes: Undiagnosed Diabetes

Scottish Public Health Observatory (ScotPHO) undiagnosed diabetes Scotland's Public Health Observatory (ScotPHO) has released a report on undiagnosed cases of diabetes across Scotland. The report uses the PBS model that INIsPHO has adapted for use on ...

COPD prevalence estimates

The Association of Public Health Observatories has published updated prevalence estimates of COPD for post October 2006 PCT populations to incorporate new rural classification of PCTs and new modelled smoking estimates and Local authority estimates of COP ...

Cancer Incidence in England by Deprivation, 1995-2004

This report from the National Cancer Intelligence Network (NCIN) provides analyses for patients diagnosed in two five-year time periods 1995-99 and 2000-04 for 23 of the more common cancer sites or groups, and for an overall grouping of all malignancies c ...