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Cochrane Reviews

Biopsy versus resection for the management of low-grade gliomas

Veeravagu, A., et al Clinical effectiveness, Biopsy, Surgical resection, Patient, Lesion, LGG Low-grade gliomas (LGG) are slow growing, less aggressive brain tumors. There are two surgical management strategies (treatments) for a person with a suspected L ...

Alginate dressings for venous leg ulcers

O'meara, S. and Martyn-St james, M. Dressing, Non-dressing treatment, Compression therapy, Venous leg ulcers. Venous leg ulcers are a common and recurring type of chronic or complex wound which can be distressing for patients and costly to healthcare ...

Magnesium sulfate for treating exacerbations of acute asthma in the emergency department

Rowe, B.H., et al Intravenous magnesium sulfate, Patients, Acute asthma, Emergency department In an asthma attack, the airways (passages to the lungs) narrow from muscle spasms and swelling (inflammation). Bronchodilator drugs (reliever inhalers) can be u ...

Transabdominal pre-peritoneal (TAPP) vs totally extraperitoneal (TEP) laparoscopic techniques for inguinal hernia repair

Wake, B.L. To compare the clinical effectiveness and relative efficiency of laparoscopic TAPP and laparoscopic TEP for inguinal hernia repair An inguinal hernia is a weakness in the wall of the abdominal cavity that is large enough to allow escape of soft ...

Vaccines for measles, mumps and rubella in children

Demicheli, V., et al To assess the effectiveness and adverse effects associated with the MMR vaccine in children up to 15 years of age Measles, mumps and rubella (MMR) are three very dangerous infectious diseases which cause severe morbidity, disability a ...

Pharmacotherapy for mild hypertension

Diao, D., et al To quantify the effects of antihypertensive drug therapy on mortality and morbidity in adults with mild hypertension Individuals with mildly elevated blood pressures, but no previous cardiovascular events, make up the majority of those con ...

Rehabilitation for ankle fractures in adults

Chung-Wei, C.L., et al To assess the effects of rehabilitation interventions following conservative or surgical treatment of ankle fractures in adults. Ankle fracture is one of the most common fractures of the lower limb, especially in older women and you ...

Interventions for erosive lichen planus affecting mucosal sites

Cheng, S., et al Erosive lichen planus, Oral region, Anogenital region, Oesophageal region Erosive lichen planus (ELP) is a condition that affects the mouth, oesophagus (food pipe or gullet), and anogenital region. It is caused by an over-active immune sy ...

Single dose dipyrone for acute postoperative pain

Derry, S., et al To assess the efficacy and adverse events of single dose dipyrone in acute postoperative pain Dipyrone is a popular medicine for pain relief in many countries and is used to treat postoperative pain, colic pain, cancer pain and migraine. ...

Interventions for preventing falls in older people living in the community

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Exercise for depression

Rimer, J., et al Sepression, Drop-outs, Exercise, Costs, Quality of life Depression is a common and disabling illness, affecting approximately 121 million adults worldwide. While depression is commonly treated with antidepressants or psychological therapy ...

Treatment for superficial thrombophlebitis of the leg

Di Nisio, M., et al To assess the efficacy and safety of topical, medical, and surgical treatments in patients presenting with ST of the legs Superficial thrombophlebitis (ST) is a relatively common inflammatory process associated with a blood clot (throm ...

Vitamin C for preventing and treating the common cold

hemila, H. and Chalker, E. The common cold The common cold is a major cause of visits to a doctor in high-income countries and of absenteeism from work and school. There are over 200 viruses which can cause the common cold symptoms including runny nose, c ...

Gabapentin for chronic neuropathic pain and fibromyalgia in adults

Moore, R.A., Wiffen, P.J., Derry, S. and McQuay, H.J. Neuropathic pain, Nerve damage Antiepileptic drugs like gabapentin are commonly used for treating neuropathic pain, usually defined as pain due to damage to nerves. This would include postherpetic neur ...

Statins for the primary prevention of cardiovascular disease

Taylor, F., et al Prevention of cardiovascular disease Cardiovascular disease (CVD), which comprises heart attacks (myocardial infarction), angina and strokes, is ranked as the number one cause of mortality and is a major cause of morbidity world wide. Hi ...

Wound drainage after plastic and reconstructive surgery of the breast

Stojkovic, C.A., et al To compare the safety and efficacy of the use of wound drains following elective plastic and reconstructive surgery procedures of the breast Plastic and reconstructive surgery of the breast can include breast enlargement, breast red ...

Withdrawal versus continuation of chronic antipsychotic drugs for behavioural and psychological symptoms in older people with dementia

Declercq, T., et al To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia in community or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older people with deme ...

Vasopressin and its analogues for the treatment of refractory hypotension in neonates

shivanna, B., et al The rimary objective was to evaluate the efficacy and safety of vasopressin and its synthetic analogues (e.g. terlipressin) in decreasing mortality and adverse neurodevelopmental outcomes, and improving survival in neonates with refrac ...

Thromboprophylaxis for trauma patients

Barrera, L.M., et al To assess the effects of thromboprophylaxis in trauma patients on mortality and incidence of deep vein thrombosis and pulmonary embolism. To compare the effects of different thromboprophylaxis interventions and their effects according ...

The role of maintenance therapy in acute promyelocytic leukemia in the first complete remission

Muchtar, E., et al To examine the efficacy and safety of maintenance therapy in APL patients and to establish the optimal regimen for maintenance Acute promyelocytic leukemia (APL) is a subtype of acute myelogenous leukemia (AML), comprising about 10% of ...