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Reports

IFN-? Production by Amyloid?-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease.

MILLS, KINGSTON; LYNCH, MARINA ANNETTA; Th1 cells; Alzheimer?s disease (AD) is characterized by the presence of amyloid-b (Ab)?containing plaques, neurofibrillary tangles, and neuronal loss in the brain. Inflammatory changes, typified by activated microgl ...

Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction.

LYNCH, MARINA ANNETTA; JAK-STAT signaling; Increasing global birth rate, coupled with the aging population surviving into their eighth decade has lead 26 to increased incidence diseases, hitherto designated as rare. Brain related ischemia, at birth, or la ...

The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease.

LYNCH, MARINA; Alzheimer's disease; Neuroinflammatory changes are a characteristic of several, if not all, neurodegenerative diseases including Alzheimer?s disease (AD) and are typified by increased microglial activation. Microglia express severa ...

Assessing neuronal networks: Understanding Alzheimer's disease

HAMPEL, HARALD; BOKDE, ARUN LAWRENCE WARREN; Psychiatry; Findings derived from neuroimaging of the structural and functional organization of the human brain have led to the widely supported hypothesis that neuronal networks of temporally coordinated brain ...

The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice.

MCLOUGHLIN, DECLAN; Psychiatry; peer-reviewed Mental Health Research and Evaluation Report http://hdl.handle.net/2262/34688 © Public Article RIAN American Society for Biochemistry and Molecular Biology Yes PeerReviewed TCDPeerReviewed 2003 Journal article ...

X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.

MC LOUGHLIN, DECLAN; Psychiatry; Increased production and deposition of amyloid?-protein (A?) are believed to be key pathogenic events in Alzheimer?s disease. As such, routes for lowering cerebral A? levels represent potential therapeutic targets for Alzh ...

Psychiatric Genetics in the post genome age

CORVIN, AIDEN; GILL, MICHAEL; Psychiatry; peer-reviewed Mental Health Research and Evaluation Report http://hdl.handle.net/2262/34987 © Public Article RIAN The Royal College of Psychiatrists Yes PeerReviewed TCDPeerReviewed 2003 Journal article applicatio ...

Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31

GILL, MICHAEL; SEGURADO, RICARDO; Psychiatry; peer-reviewed Mental Health Research and Evaluation Report http://hdl.handle.net/2262/34993 Article RIAN American Psychiatric Association Yes PeerReviewed TCDPeerReviewed 2005 Journal article application/pdf S ...

Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q

GILL, MICHAEL; Psychiatry; peer-reviewed Mental Health Research and Evaluation Report http://hdl.handle.net/2262/35086 © Public Article RIAN Elsevier Yes PeerReviewed TCDPeerReviewed 2005 Journal article application/pdf McQueen M, Devling B, Faraone S, Vi ...

Is 'Clinical' insight the same as 'Cognitive' insight in schizophrenia?

CORVIN, AIDEN PETER; GILL, MICHAEL; HAYDEN, JUDY; Schizophrenia; Cognition; Insight; Cognitive failures; Sustained attention; Memory; Working memory; Poor insight is associated with impaired cognitive function in psychosis. Whether poor clinical insight o ...

Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease

HAMPEL, HARALD; BOKDE, ARUN LAWRENCE WARREN; Psychiatry; Subjects with mild cognitive impairment (MCI) have an increased risk to develop Alzheimer?s disease (AD). Voxel-based MRI studies have demonstrated that widely distributed cortical and subcortical b ...

The Depression Network (DeNT) Study: Methodology and Sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetics study

GILL, MICHAEL; Psychiatry; Background: The Depression Network Study (DeNt) is a multicentre study designed to identify genes and/or loci linked to and/or associated with susceptibility to unipolar depression in Caucasian families. This study presents the ...

Whole genome linkage scan of recurrent depressive disorder from the depression network study

GILL, MICHAEL; Psychiatry; Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female?fema ...

Genetic mouse models of Alzheimer's disease.

MCLOUGHLIN, DECLAN; Psychiatry; peer-reviewed Mental Health Research and Evaluation Report http://hdl.handle.net/2262/33189 © Public Article RIAN Freund and Pettman Yes PeerReviewed TCDPeerReviewed 2005 Journal article application/pdf Mineur Y.S., McLough ...

Total and phosphorylated Tau protein as biological markers of Alzheimer's disease

HAMPEL, HARALD; Alzheimer?s disease; MCI; neurodegeneration; biomarker; prediction; diagnosis; blood; CSF; tau; p-tau; peer-reviewed Mental Health Research and Evaluation Report http://hdl.handle.net/2262/34386 Article RIAN Elsevier Yes PeerReviewed TCDPe ...

The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report

CORVIN, AIDEN PETER; GILL, MICHAEL; SEGURADO, RICARDO; Genetics; Linkage; lod score; manic-depressive; microsatellite repeats; We have completed the first stage of a two-stage genome wide screen designed to identify chromosomal regions that may harbour su ...

Depression, anxiety and cardiovascular disease: Which symptoms are associated with increased risk in community dwelling older adults?

KENNY, ROSE ANNE; O'REGAN, CLAIRE; LAWLOR, BRIAN; SAVVA, GEORGE; CRONIN, HILARY; cardiovascular risk; Depression is a risk factor for Cardiovascular Disease (CVD). It has been reported that somatic symptoms of depression and not cognitive symptom ...

Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder

GILL, MICHAEL; SEGURADO, RICARDO; Psychiatry; Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to iden ...

Cigarette smoking and psychotic symptoms in bipolar affective disorder

CORVIN, AIDEN PETER; GILL, MICHAEL; Psychiatry; Background An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Aims To determine whether smoking is associated with psychosis in bip ...

Psychosis Susceptibility Gene ZNF804A and Cognitive Performance in Schizophrenia

CORVIN, AIDEN; Psychiatry; Schizophrenia; ZNF804A; Genes & Society; Neuroscience; Background: The Zinc Finger Protein 804A gene (ZNF804A) has been implicated in schizophrenia (SZ) susceptibility by several genome-wide association studies (GWAS). Z ...