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Systematic reviews

Central Retinal Enrichment Supplementation Trials (CREST): Design and Methodology of the CREST Randomized Controlled Trials

Akuffo KO, Beatty S, Stack J, Dennison J, O'Regan S, Meagher KA, Peto T, Nolan JM Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease P urpose: The Central Retinal Enrichment Supplementation Trials (CREST) aim to investigate the ...

Verification of Meso-Zeaxanthin in Fish

Nolan JM, Beatty S, Meagher KA, Howard AN, Kelly D, Thurnham DI Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease A bstract Background/Objectives: The carotenoids lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) accumulate in th ...

SUPPLEMENTATION WITH THREE DIFFERENT MACULAR CAROTENOID FORMULATIONS IN PATIENTS WITH EARLY AGE-RELATED MACULAR DEGENERATION

Sabour-Pickett S, Beatty S, Connolly E, Loughman J, Stack J, Howard AN, Klein R, Klein BE, Meuer SM, Myers CE, Akuffo KO, Nolan JM Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease P urpose: To investigate the impact of three differ ...

Measuring Visual Function Using the MultiQuity System:Comparison with an Established Device

Smolarek-Kasprzak P, Nolan JM, Beatty S, Dennison J, Akuffo KO, Kuchling R, Stack J, O'Regan G Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease Purpose. To compare measures of visual acuity (VA) and contrast sensitivity (CS) f ...

The Impact of Supplemental Macular Carotenoids in Alzheimer’s Disease:A Randomized Clinical Trial

Nolan JM. Loskutova E. Howard A. Mulcahy R. Stack J. Bolger M. Coen RF. Dennison J. Akuffo KO. Owens N.Power R. Thurnham D. Beatty S. Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease Abstract. Background: Patients with Alzheimer’s ...

Sustained supplementation and monitored response with differing carotenoidformulations in early age-related macular degeneration

Akuffo BO. Nolan JM. Howard AN. Moran R. Klien R. Klien BE. Meuer SM. Sabour-Pickett S. Thumham DI. Beatty S. Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease To compare the impact of sustained supplementation using different macul ...

Prevalence of age-related macular degeneration inthe Republic of Ireland

Akuffo BO. Nolan JM. Stack J. Moran R. Feeney J. Kenny RA. Peto T. Dooley C. Corcoran AM. Cronin H. Beatty S. Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease ABSTRACT Background Age-related macular degeneration (AMD) remains the m ...

Cognitive Function and Its Relationshipwith Macular Pigment Optical Density and Serum Concentrations of its Constituent Carotenoids

Kelly D. Coen RF. Akuffo BO. Beatty S. Dennison J. Moran R. Stack J. Howard AN. Mulcahy R. Nolan JM. Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease A bstract. Background: Macular pigment (MP) levels correlate with brain concentra ...

Visual Function and Its Relationship with Severity of Early, and Activity of Neovascular, Age-Related Macular Degeneration

Loughman J. Sabour-Pickett S. Nolan JM. Klien B. Klien R. Beatty S. Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease Purpose: To investigate the relationship between visual function and severity of early age-related macular degener ...

Assessment of lutein, zeaxanthin andmeso-zeaxanthin concentrations in dietary supplements by chiral high-performance liquid chromatography

Prado-Cabrero A. Beatty S. Stack J. Howard AN. Nolan JM Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease Abstract We investigated the concordance between actual and declared content of the three macular carot- enoids in commerciall ...

Concordance of Macular Pigment Measurement Using Customized Heterochromatic Flicker Photometry and Fundus Autofluorescence in Age-Related Macular Degeneration

Prado-Cabrero A. Beatty S. Stack J. Howard AN. Nolan JM Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease P URPOSE. We compared macular pigment (MP) measurements using customized heterochro- matic flicker photometry (Macular Metrics ...

Lutein, zeaxanthin andmeso-zeaxanthin content of eggs laid by hens supplemented with free and esterified xanthophylls

Nolan JM. Meagher KA. Howard AN. Moran R. Thumham DI. Beatty S Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease Abstract The xanthophyll carotenoids lutein (L), zeaxanthin (Z) and meso-zeaxanthin (MZ) are found at the macula, the c ...

The Impact of Cataract, and Its Surgical Removal, on Measures of Macular Pigment Using the Heidelberg Spectralis HRAþOCT MultiColor Device

Akuffo BO. Nolan JM. Stack J. Power R. Kirwan C Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease P URPOSE. To investigate the effect of cataract (and cataract surgery) on macular pigment (MP) measurements using the Heidelberg Spect ...

Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: Central Retinal Enrichment Supplementation Trials – Report 1

Nolan JM. Power R. Stringham J. Dennison J. Stack J. Kelly D. Moran R. Akuffo BO. Corcoran L. Beatty S. Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease P URPOSE. The high-performance visual function associated with central vision ...

Quantification o fzeaxanthin stereoisomers and lutein in trout flesh using chiral high-performance liquid chromatography-diode array detection

Prado-Cabrero A. Beatty S. Stack J. Howard AN. Nolan JM Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease In our previous work we identified the presence of meso-zeaxanthin[(3R,30S)- zeaxanthin] in trout flesh and skin(Nolanetal.,20 ...

The evidence informingthe surgeon’s selection of intraocular lens onthe basis of light transmittance properties

Li X. Kelly D. Nolan JM. Dennison JL. Beatty S. Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease In recent years, manufacturers and distributors have promoted commercially available intrao- cular lenses (IOLs) with transmittance pr ...

Serum and macular response to carotenoid-enriched egg supplementationin human subjects: the Egg Xanthophyll Intervention clinical Trial (EXIT)

Kelly D. Nolan JM. Howard AN. Stack J. Akuffo KO. Moran R. Themham DI. Dennison J. Meagher KA. Beatty S Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease Abstract The macular carotenoids lutein (L), zeaxanthin (Z) and meso-zeaxanthi ...

Relationship between macular pigment and visual function in subjects with early age-related macular degeneration

Akuffo BO. Nolan Jm. Peto T. Stack J. Leung I. Corcoran L. Beatty S. Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease ABSTRACT Purpose To investigate the relationship between macular pigment (MP) and visual function in subjects wit ...

Stability of Commercially Available Macular Carotenoid Supplements in Oil and Powder Formulations

Phelan D. Prado-Cabrero A. Nolan JM Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease A bstract: We previously identified that the concentration of zeaxanthin in some commercially available carotenoid supplements did not agree with ...

NON-DIETARY CORRELATES AND DETERMINANTS OF PLASMA LUTEIN AND ZEAXANTHIN CONCENTRATIONS IN THE IRISH POPULATION

Moran R. Nolan JM. Stack J. O'Halloran AM. Feeney J. Akuffo Ko. Kenny RA. Beatty S. Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease Abstract: Objective: To investigate non-dietary correlates and determinants of plasma lutein ...