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The effect of obesity combined with low muscle strength on decline in mobility in older persons

S Stenholm, D Alley, S Bandinelli, M E Griswold, S Koskinen, T Rantanen, J M Guralnik and L Ferrucci1 Research on the effect of obesity on the mobility of older people Both obesity and muscle impairment are increasingly prevalent among older persons and n ...

Vegetables and nuts come out top for heart health

A. Mente, L. de Koning, H.S. Shannon, S.S. Anand A report to show that a Mediterranean diet, rich iS associated with a lower risk for heart disease According to findings published in this week's Archives of Internal Medicine, modest relationships wer ...

Sim1 Haploinsufficiency Impairs Melanocortin-Mediated Anorexia and Activation of Paraventricular Nucleus Neurons

Kublaoui, B. et al Research study on analysis of a gene implicated in human monogenic obesity Single-minded 1 (SIM1) is one of only six genes implicated in human monogenic obesity. Haploinsufficiency of this hypothalamic transcription factor is associated ...

Interventions to achieve long-term weight loss in obese older people: A systematic review and meta-analysis

1 Section of Ageing and Health, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK2 Health Services Research Unit, University of Aberdeen, Aberdeen, UK Address correspondence to: M. Witham. Tel: (+44) 1382 632436; Fax: (+44) 1382 660675. Email: ...

Stroke: Diagnosis and initial management of acute stroke and transient ischaemic attack (TIA)

National Collaborating Centre for Chronic Conditions Diagnosis and initial management of acute stroke and transient ischaemic attack (TIA) Diagnosis and initial management of acute stroke and transient ischaemic attack (TIA) The advice in the NICE guideli ...

Putting a health inequalities focus on the Northern Ireland cardiovascular service framework

The PHA, supported by the Institute of Public Health in Ireland (IPH) and other agencies and individuals, has completed a health impact assessment (HIA) on the Cardiovascular Service Framework (CVSFW) for Northern Ireland.The CVSFW is the first in a serie ...

The differential impact of subjective and objective aspects of social engagement on cardiovascular risk factors

WHELAN, BRENDAN JAMES; TIMONEN, VIRPI; KAMIYA, YUMIKO; KENNY, ROSE ANNE; Gerontology; Cardiovascular disease (CVD); Background: This article provides new insights into the impact of social engagement on CVD risk factors in older adults. We hypothesized th ...

Bi-directional gene set enrichment and canonical correlation analysis identify key diet-sensitive pathways and biomarkers of metabolic syndrome.

Morine, Melissa J; McMonagle, Jolene; Toomey, Sinead; Reynolds, Clare M; Moloney, Aidan P; Gormley, Isobel C; Gaora, Peadar Ó; Roche, Helen M.; Trans-11-Conjugated Linoleic-Acid; Cholesterol-Biosynthesis; Cardiovascular Mortality; Lipoprotein Metabolism; ...

The tromped, a means of prophylaxis for flight related deep vein thrombosis

Collins, Carolyn, (Thesis); tromped; prophylaxis; flight related deep vein thrombosis; mechanical aids; Medical engineering; Biomedical Engineering and Bioengineering; The process of blood flow in the leg, against gravity and towards the heart is instigat ...

A generic approach to supporting the management of computerised clinical guidelines and protocols

Dube, Kudakwashe, (Thesis); Healthcare; Clinical guidelines or protocols (CGPs) are statements that are systematically developed for the purpose of guiding the clinician and the patient in making decisions about appropriate healthcare for specific clinica ...

The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3

O'NEILL, LUKE ANTHONY JOHN; TANNAHILL, GILLIAN; Immunology; Toll-like receptors (TLRs); While it has long been suspected that inflammation participates in the pathogenesis of metabolic disorders such as the insulin resistance that occurs in type ...

Access to health care of persons with disabilities as an indicator of equity in health systems

MANNAN, HASHEEM; Global Health; Equity; The outcomes of certain health services can be used to assess the overall effectiveness of a health care system. For example, maternal mortality is an indicator of the quality of a country’s maternal health services ...

Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3

FINLAY, DAVID; Genetics; Diabetes; Glucose; Glycogen synthase kinase-3 (GSK3); GSK3 (glycogen synthase kinase-3) regulation is proposed to play a key role in the hormonal control of many cellular processes. Inhibition of GSK3 in animal models of diabetes ...

Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element

FINLAY, DAVID; Genetics; GSK-3; Insulin; IGFBP-1 gene transcription; Background: Hepatic expression of several gene products involved in glucose metabolism, including phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase) and insulin-li ...

A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression

FINLAY, DAVID; Genetics; Insulin; Insulin regulation of hepatic gene transcription is a vital component of glucose homeostasis. Understanding the molecular regulationof thisprocess aids the searchfor the defect(s) that promotesinsulin-resistant states, su ...

Possible Interacting Proteins for Retinol Binding Protein and Cellular Retinol Binding Protein

Cooney, David; Biology; Interacting Proteins; Retinol Binding Protein; Cellular Retinol Binding Protein; Retinol or vitamin A is crucial for many biological processes in the body such as proliferation, differentiation and reproduction. It is mainly stored ...

Building Healthier Hearts: The Report of the Cardiovascular Health Strategy Group

10.6.1999 This introduction to â?~Building Healthier Heartsâ?T will give readers an overview of the report of the Cardiovascular Health Strategy Group. Firstly, it sets out the background to the strategy and its policy context. A brief description of mort ...

Your Health Matters: Annual Report of the Chief Medical Officer for Northern Ireland 2012/13

Chief Medical Officer (NI) Health of the population of Northern Ireland ‘Stay active, stay healthy, and live longer’ was the message from NI Chief Medical Officer (CMO) Dr Michael McBride as he launched his annual report. Dr McBride said that while there ...

Belfast Healthy Hearts Programme

Belfast Partnership Boards and the Public Health Agency (PHA) Cardiovascular health 'Healthy Hearts in the West’ is one of the Belfast Healthy Hearts Programmes funded by the Public Health Agency. It is a Cardiovascular Strategy for West Belfast and ...

Children and Young People Statistics 2013

British Heart Foundation (BHF) Heart Conditions This publication is designed for health professionals, medical researchers and anyone with an interest in the health of children or cardiovascular disease. It is divided into three sections – congenital hear ...