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Parental history of Alzheimer disease associated with lower plasma apolipoprotein E levels

Creator:

American Academy of Neurology

Topic: Chronic Conditions
Coronary Heart Disease (CHD)
Hypertension
Stroke
Conditions
Type: Report
Region: International (other)
Description:

From the Department of Gerontology and Geriatrics (P.v.V., R.G.J.W.), Department of Clinical Chemistry (M.F.), and Department of Clinical Genetics, Center for Human and Clinical Genetics (E.B.), Leiden University Medical Center; Department of Psychiatry (P.E., H.C.C., E.v.E.), VU Medical Center/SGB, Amsterdam; Department of Neurology (P.E.), Academic Medical Center, Amsterdam; and Department of Neurology (W.v.d.F.), VU Medical Center, Amsterdam, The Netherlands.Address correspondence and reprint requests to Dr. P. van Vliet, Leiden University Medical Center, Department of Gerontology and Geriatrics (C2-R), PO Box 9600, 2300 RC, Leiden, The Netherlands p.van_vliet@lumc.nl Background: Variation in APOE genotype is a determinant of Alzheimer disease (AD), but the risk associated with variation in plasma apoE levels has yet to be determined. Here, we studied offspring with and without a parental history of AD to identify the effect of plasma apoE levels at middle age on the risk of late-onset AD.Methods: Some 203 offspring from 92 families with a parental history of AD were compared with 197 offspring from 97 families without a parental history of AD. APOE genotypes and plasma apoE levels were assessed in all offspring. Difference in plasma apoE level between subjects with and without a parental history of AD was calculated using robust linear regression, both stratified and adjusted for APOE genotype.Results: Offspring with a parental history of AD were more likely to be an APOE 4 allele carrier (46% vs 21%, p < 0.001) than offspring without such a parental history. Mean plasma apoE levels strongly decreased from 2 to 33 to 4 carriers (p < 0.001). Offspring with a parental history of AD had lower plasma apoE levels than subjects without such a history, both in analyses adjusted for APOE genotype (difference: –0.21 mg/dL, p = 0.02) and when using standardized Z scores, when stratified for APOE genotype (difference: –0.22, p = 0.009).Conclusions: Our findings suggest that lower plasma apoE levels in middle age could be a risk factor for Alzheimer disease in old age, independent of APOE genotype. Abbreviations: AD = Alzheimer disease; BMI = body mass index; CI = confidence interval; CVD = cardiovascular disease; EOAD = early-onset Alzheimer disease; HDL = high-density lipoprotein; LDL = low-density lipoprotein; LOAD = late-onset Alzheimer disease; MMSE = Mini-Mental State Examination; VaD = vascular dementia.

Date:

08/09/2009

Rights: Public
Suggested citation:

American Academy of Neurology. (2009) Parental history of Alzheimer disease associated with lower plasma apolipoprotein E levels [Online]. Available from: http://publichealthwell.ie/node/9474 [Accessed: 21st October 2019].

  

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