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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Creator:

Science

Topic: Chronic Conditions
Coronary Heart Disease (CHD)
Hypertension
Stroke
Conditions
Type: Report
Region: International (other)
Description:

Ricki J. Colman,1,* Rozalyn M. Anderson,1 Sterling C. Johnson,1,2,3 Erik K. Kastman,2,3 Kristopher J. Kosmatka,2,3 T. Mark Beasley,4 David B. Allison,4 Christina Cruzen,1 Heather A. Simmons,1 Joseph W. Kemnitz,1,2,5 Richard Weindruch1,2,3,*Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species. 1 Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA.2 Department of Medicine, University of Wisconsin, Madison, WI 53706, USA.3 Geriatric Research, Education, and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA.4 Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.5 Department of Physiology, University of Wisconsin, Madison, WI 53706, USA. * To whom correspondence should be addressed. E-mail: rcolman@primate.wisc.edu (R.J.C.); rhweindr@wisc.edu (R.W.)

Date:

16/07/2009

Rights: Public
Suggested citation:

Science. (2009) Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys [Online]. Available from: http://publichealthwell.ie/node/9356 [Accessed: 21st October 2019].

  

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