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The angiogenic response to skeletal injury is preserved in the elderly

Creator:

Journal of Orthopaedic Research

Type: Report
Region: Northern Ireland
Description:

Angiogenesis is essential for normal bone formation and repair. Avascularity characterizes aberrant fracture union in the elderly, while angiogenic mechanisms during cutaneous wound repair are attenuated in aged humans. We hypothesized that skeletal injury results in local (circulating) and systemic (fracture site) angiogenic responses and that these reparative mechanisms are attenuated with advanced patient age. This prospective study examined peripheral blood and fracture hematoma from 32 patients, 16 under 40 years and 16 over the age of 75, undergoing emergent surgery for isolated fracture. The angiogenic cytokines vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) were assayed.

Date:

18/02/2008

Rights: Public
Suggested citation:

Journal of Orthopaedic Research. (2008) The angiogenic response to skeletal injury is preserved in the elderly [Online]. Available from: http://publichealthwell.ie/node/5632 [Accessed: 21st August 2019].

  

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Contributor:

CARDI
 
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