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Pathogens, Vol. 6, Pages 26: IgG Avidity Test in Congenital Toxoplasmosis Diagnoses in Newborns

18 Jun 2017

Pathogens, Vol. 6, Pages 26: IgG Avidity Test in Congenital Toxoplasmosis Diagnoses in Newborns

Pathogens doi: 10.3390/pathogens6020026

Authors:
Zulmirene Cardoso Fonseca
Isolina Maria Xavier Rodrigues
Natália Cruz e Melo
Juliana Boaventura Avelar
Ana Maria Castro
Mariza Martins Avelino

The goal of this study was to investigate the importance of IgG avidity testing in newborns (NBs) diagnosed with early congenital toxoplasmosis. We collected samples from 88 puerperae infected by Toxoplasma gondii (T. gondii) and their NBs (48 acutely-infected puerperae (AIP) and 40 chronically-infected puerperae (CIP)), from two public maternity hospitals in Goiania city, Goias, Brazil, from 2010 to 2015. Specific anti-T. gondii IgM and IgG serum levels and IgG avidity tests were evaluated using chemiluminescence. Congenital toxoplasmosis was observed in 66.66% (n = 32) of NBs with AIP, 94.1% presenting low avidity (LA) and 51.61% presenting high avidity (HA) test results. The IgG and IgM levels of NBs with LA and their puerperae were higher in comparison with HA NBs and puerperae (p = 0.0001). The avidity tests showed 100% specificity and 50% sensitivity (p = 0.0001). NBs with LA had a 15-fold increased risk of developing congenital toxoplasmosis in comparison with HA NBs. The IgG avidity test could be used to assist in early congenital toxoplasmosis diagnoses in NBs and LA, identifying a greater probability of vertical transmission.

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