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Biology, Vol. 5, Pages 12: Melatonin and Sleep-Wake Rhythms before and after Ocular Lens Replacement in Elderly Humans

15 Feb 2016

Biology, Vol. 5, Pages 12: Melatonin and Sleep-Wake Rhythms before and after Ocular Lens Replacement in Elderly Humans

Biology doi: 10.3390/biology5010012

Authors:
Marina Giménez
Domien Beersma
Serge Daan
Bert Pol
Martijn Kanis
Dick van Norren
Marijke Gordijn

Light of short wavelengths has been shown to play a key role in non-image forming responses. Due to aging, the ocular lens becomes more yellow reducing the transmission of short wavelengths in the elderly. In the present study, we make use of cataract surgery to investigate the effects of a relative increase of short wavelength transmission on melatonin- and sleep-wake rhythms (N = 14). We observed, on average, a delay of the sleep-wake and the nocturnal melatonin rhythms after cataract surgery. This delay is tentatively attributed to a relatively large increase of light transmittance in the evening hours more than an increase of the already relatively high light intensities found in the daytime. The later phase that we observed after cataract surgery (clear lens) as compared to the earlier phase observed before cataract (yellowish lens) is in agreement with the general later phase reported in the young (clear lens) population.

Click here to view the full article which appeared in Biology